The 9th BBBNedwork meeting will be held at Friday 10 March 2023
Biopartner Auditorium (building 1), J.H. Oortweg 21, Bioscience Park, Leiden.
The 8th BBBNedwork meeting will be held at Friday 25 March 2022
Biopartner Auditorium (building 1), J.H. Oortweg 21, Bioscience Park, Leiden.
7th BBB Nedwork meeting
Friday 15 March 2019, 10.00-18.00: Biopartner Auditorium, J.H. Oortweg 21, Leiden Bioscience Park
6th BBB Nedwork meeting
Friday 16 March 2018, 10.00-18.00: Biopartner Auditorium, J.H. Oortweg 21, Leiden Bioscience Park
| 10:00 – 10:30 | Registration and Coffee |
| 10:30 – 10:45 | Welcome and introduction new partners |
| 10:45 – 11:15 | Ronald Borra, UMCG |
| ”MRI perfusion and HIFU technology” | |
| 11:15 – 11:45 | Nienke Wevers, Mimetas |
| ”BBB-on-a-chip: a 3D vitro model of the human blood-brain barrier" | |
| 11:45 – 12:15 | Dennis van Vuurden, VUmc |
| ”Drug delivery over the BBB in high grade gliona: focused ultrasound and convection enhanced delivery” | |
| 12:15 – 13:00 | Lunch Break |
| 13:00 – 14:00 | Workshops: |
| Good academic research practice (Dirk-Jan vd Berg, LACDR) | |
| Multiscale designed experiments & modelling (Mastermind Reserach Approach, Liesbeth de Lange, LACDR) | |
| Measurements of drug transport with PET (Gert Luurtsema, UMGC) | |
| 14:00 – 14:30 | Annebet Leeuwis, Alzheimer centrum VUmc |
| “Microbleed in AD” | |
| 14:30 – 14:45 | Tian Qin, LACDR |
| “Towards an extracellular vesicle based liquid biopsy for early stage Alzheimer s Disease" | |
| 14:45 – 15:15 | Tea Break |
| 15:15 – 15:30 | Lara Garcia Varela, UMCG |
| ”Anesthesia affects P-glycoprotein function at the blood-brain barrier" | |
| 15:30 – 15:45 | Diede Broekaart, AMC |
| "Matrix metalloproteinases in human and experimental temoral lobe epilepsy" | |
| 15:45 – 16:00 | Closing Remarks |
| 16:00 – 18:00 |
Drinks |
5th BBB Nedwork meeting
Friday 17 March 2017, 10.00-18.00: Biopartner Auditorium, J.H. Oortweg 21, Leiden Bioscience Park
4th BBBNedwork meeting
Friday 18 March 2016, 10.30 - 18.00: Biopartner Auditorium, J.H. Oortweg 21, Leiden Bioscience Park
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10.00 - 10.30 |
Registration and Coffee |
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10.30 - 10.45 |
Welcome and introduction new partners |
| 10.45 - 11.00 |
Inge Zuhorn (UMCG) Development of vectors for gene deivery to the central nervous system |
| 11.00 - 11.15 |
Heli Savolainen (UMCG), PET imaging of functional P-gp in rats – diurnal fluctuations and sleep deprivation |
| 11.15 - 11.30 |
Nienke de Wit (VUmc), Role of nuclear receptors in BBB function |
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11.30 - 12.15 |
Keynote: Prof. dr. Peter de Boer (Johnson & Johnson) Translation of animal data to the clinic: challenges in psychiatric drug development |
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12.15 - 13.15 |
Lunch and break out sessions |
| 13.15 - 13.45 |
Dr. Pieter Gaillard (2 BBB) and dr. Eric Ronken (DII BV), Future of scientist in industry – career management |
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13.45 - 14.15 |
Dr. Morola Lipzig (TNO), Quantification of ABC transporter protein expression in rat brain with LC-MS |
| 14.15 - 14.45 |
Dr. Matthias J.P. van Osch (LUMC), Imaging of subtle BBB-damage by MRI |
| 14.45 - 15.00 |
Tea time |
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15.00 - 15.15 |
Anne-Eva van Wijk (AMC), TNFa and cAMP in blood-retinal barrier |
| 15.15 - 15.30 |
Dr. Erwin van Vliet (AMC), Anatoly Korotkov, Extracellular matrix molecules and modulation by miRNAs in epilepsy |
| 15.30 - 16.00 | Prof. dr. Bart van Berckel (Vumc), PET imaging of ABC transporters at the BBB in Alzheimer s disease |
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16.00 - 18.00 |
Closing remarks and Drinks |
3rd BBBNedwork meeting
Friday 20 March 2015, 
10.30 - 16.30: Biopartner Auditorium, J.H. Oortweg 21, Leiden Bioscience Park
Participant information slides (2015) & Photos from the 2015 meeting
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Registration and Coffee |
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10.30 |
Welcome and introduction |
| Valeria Orlova (LUMC) – Modeling of neurovascular diseases with human induced pluripotent stem cells | |
| Claudio Derada Troletti(MCBI, VUmc) - Molecular control of the BBB | |
| Marinke van der Helm (BIOS Lab on a Chip, TU) A microfluidic platform to study and modulate the blood-brain barrier | |
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Keynote: Dr. Matthew Campbell (Trinity College, Dublin, Ireland) - RNAi-mediated modulation of the BBB: from basic to apllied science. |
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12.30 - 14.00 |
Lunch and break out sessions |
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Roundtable discussions |
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14.00 |
Reinier Schlingemann (Ophthalmology, AMC) – PLVAP at the BRB/BBBThe role of PLVAP in regulating vascular permeability and angiogenesis-relevance for the blood-brain and blood-retinal barriers |
| Lisanne van Leeuwen (Medical Microbiology, VUmc) Mycobacterium marinum can cross the blood-brain barrier via different migration routes | |
| Tonny Lageweij (Neuro-oncology, VUmc) – 3D imaging and modeling of the brain vasculature | |
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Diewertje Bink (Pathology, AMC) – Intracranial atherosclerosis, cholesterol and the BBB |
| Gert Luurtsema (UMCG, Groningen) - PET imaging of ABC transporters at the BBB: where are we now? | |
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15.45 |
Closing remarks and Drinks |
2nd BBBNedwork meeting
Friday 21 March 2014, 10.30 - 16.3010.30 - 16.30: Leiden Bioscience Park
Information slides of participants at the BBBNedwork meetings
A Photo Impression (for all photos see picasa):
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Program
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10.00 – 10.30 |
Registration and Coffee |
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10.30 |
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Erwin van Vliet, Center for Neuroscience, Swammerdam Institute for Life Sciences, UvA, Amsterdam. Sequential magnetic resonance imaging after status epilepticus reveals differential effects of rapamycin on blood-brain barrier function in the rat |
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Renske Raaphorst, Department of Radiology & Nuclear Medicine, VUmc, Amsterdam. Evaluation of a new fluorine-18 labelled verapamil analogue for investigating P-gp function |
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Laura Kervezee, Laboratory of Neurophysiology, Department of Molecular Cell Biology, LUMC and Division of Pharmacology, LACDR, Leiden. Diurnal variation in P-glycoprotein mediated transport and cerebrospinal fluid turnover in the central nervous system |
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Keynote: Perry Calias, Shire, Boston, US. Intrathecal Delivery of Protein Therapeutics to the Brain: A Critical Reassessment. |
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12.15 – 14.15 |
Lunch break & roundtable discussions |
| Business Meeting to discuss the future of BBBNedwork | |
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Mark Mizee, Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VUmc, Amsterdam. Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function during neuroinflammation in multiple sclerosis. |
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Joanna Wisniewska-Kruk, Ocular Angiogenesis Group, Department of Ophthalmology and Cell Biology and Histology, AMC, UvA, Amsterdam. The role of plasmalemma vesicle-associated protein in blood retinal barrier permeability |
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David Maussang, to-BBB technologies BV, Leiden. Glutathione PEGylated liposomes: unraveling the mechanism for enhanced drug delivery to the brain |
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Mieke de Jager, Department of Anatomy and Neurosciences, Cellular Neuropharmacology section, Neuroscience Campus Amsterdam, VUMc, Amsterdam. The blood-derived transglutaminase Factor XIII colocalises with Aβ deposition in cerebral amyloid angiopathy and forms complexes with Aβ in vitro |
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Patrick de Boer, ttopstart, Bilthoven. Grant writing |
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Closing remarks |
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16.15 |
Drinks |
Roundtable discussions (25 minutes)
1. Patent and/or Publish?! (Pieter Gaillard, to-BBB technologies BV, Leiden)
Similarities and differences between academic and company research
2. Top models (Liesbeth de Lange, Division of Pharmacology, LACDR, Leiden)
Use of models to understand relationships between multiple parameters.
3. Crossing barriers (Arie Reijerkerk, to-BBB technologies BV, Leiden)
Extending blood-brain barrier research to the eye
4. Imagination (Elga de Vries, Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VUmc, Amsterdam and Bert Windhorst, Department of Radiology & Nuclear Medicine, VUmc, Amsterdam)
Visualize BBB dynamics using imaging techniques
Keynote Speaker: Dr. Perry Calias
Perry Calias specializes in the development of targeted therapies. As Senior Director for Shire HGT, he has championed the investigational effort for the intrathecal administration of recombinant enzymes for the treatment of the CNS manifestations associated with lysosomal diseases. In this capacity, he has led the research effort with regards to regulatory filings both within the US and abroad resulting in 3 clinical trials and several peer-reviewed articles. He has held various R&D positions at EyeGate Pharmaceuticals (Vice President, Research and Development), Eyetech Pharmaceuticals (Senior Director, Drug Delivery/Chemistry) and Draper Laboratories (Senior Technical Lead), and Genzyme Corporation (Senior Scientist, Biomaterials and Surgical Products Research Department). Dr. Calias is listed as an inventor on over 30 domestic and foreign patents/applications spanning 18 different patent families, including mRNA therapeutics, new polyethylene glycol-linker chemistries, noninvasive ocular delivery devices, nucleic acid-protecting strategies, and combination anti-angiogenic therapies. He obtained his Ph.D. in Bio-Organic Chemistry in 1996 and his M.S. in 1993 from Tufts University.
1st BBBNedwork kick-off meeting
Friday 22 March 2013, Leiden
Introduction slides of participants and speakers at the BBBNedwork kick-off meeting 22 March 2013
A photo impression:
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Program
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9.30 – 10.00 |
Registration and Coffee |
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10.00 – 10.10 |
Introduction BBBNedwork |
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10.10 – 11.00 |
Introduction participants |
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11.00 – 11.15 |
Elga de Vries, Blood-Brain Barrier Research group, VUmc, Amsterdam |
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11.15 – 11.30 |
Inge Zuhorn, Cell Biology-Membrane Cell Biology, UMCG, Groningen |
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11.30 – 12.15 |
Keynote: Joan Abbott, King s College, Londen, UK |
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12.15 – 14.15 |
Lunch break & visit to-BBB labs |
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14.15 – 14.30 |
Rick Dijkhuizen, Biomedical MR Imaging & Spectroscopy group, UMCU, Utrecht |
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14.30– 14.45 |
Liesbeth de Lange, Division of Pharmacology, LACDR, Leiden |
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14.45 – 15.00 |
Louise van der Weerd, Functional and Molecular MR group, LUMC, Leiden |
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15.00 – 15.15 |
William Leenders, Department of Pathology, Radboud UNMC, Nijmegen |
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15.15 – 15.30 |
Reinier Schlingemann, Medical Retina Unit and Ocular angiogenesis group, AMC, Amsterdam |
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15.30 – 16.00 |
Adriaan Lammertsma, Department of Radiology & Nuclear Medicine, Radionuclidencentrum, Amsterdam |
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16.00 – 16.15 |
Closing remarks |
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16.15 |
Drinks |