Wednesday June 22nd
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VENUE: Pieterskerk, Kloksteeg 16, Leiden
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08:00 - end
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Registration Desk Available
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Session I:
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Development, differentiation and ageing of the blood-brain barrier
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Chairs: Richard Daneman (University of California, San Francisco, USA) &
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Arie Reijerkerk (VU University Medical Center, NL)
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08:30 - 09:00
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Richard Daneman (University of California, San Francisco, USA)
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Molecular mechanisms of blood-brain barrier regulation during health and disease
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09:00 - 09:20
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Arie Reijerkerk (VU University Medical Center, NL)
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MicroRNAs control the blood-brain barrier
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09:20 - 09:40
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Annika Armulik (Karolinska Institute, SE)
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The role of pericytes at the neurovascular unit |
09:40 - 10:00
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Stefan Liebner (Edinger Institute, DE)
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Endothelial Wnt/β-Catenin signaling reduces vascularization, barrier breakdown and tumor growth in a mouse glioma model |
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10:00 - 10:45
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Break
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10:45 - 11:00
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Jorge Ivan Alvarez (University of Montreal, CAN) |
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The hedgehog pathway sustains blood-brain barrier properties |
| 11:00 - 11:15 |
Marijke de Bock (Ghent University, BE) |
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Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability |
| 11:15 - 11:30 |
Barbara Deracinois (Université Lille Nord de France, FR) |
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Proteomics of the blood-brain barrier endothelial cells: Fractionated solubilisation and LC MS/MS using label free and stable isotope labeling approaches |
| 11:30 - 11:45 |
Mark Mizee (VU University Medical Center, NL) |
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Retinoic acid induces the blood-brain barrier during human brain development |
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12:00 - 14:30
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Lunch and posters
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Poster session I (presenters at posters at 12:30) |
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Session IIA:
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Tight junctions of the blood-brain barrier [sponsored by JUST BRAIN]
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Chairs: Ingolf Blasig (University of Berlin, DE) &
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Britta Engelhardt (University of Bern, CH) |
14:30 - 14:55
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Ingolf Blasig (University of Berlin, DE)
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Principles of the molecular organization of cerebral tight junction strands
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14:55 - 15:20
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Britta Engelhardt (University of Bern, CH)
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Breaching the blood-brain barrier: the multi-step T cell adhesion cascade updated and extended |
15:20 - 15:35
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Anny-Claude Luissint (Institute Cochin, FR) |
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Guanine nucleotide-binding protein G alpha i2 (Gαi2): a partner of claudin-5 and a regulator of tight junction integrity in human brain endothelial cells |
| 15:35 - 15:50 |
Reiner Haseloff (Leibniz-Institute für Molekulare Pharmakologie, DE) |
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Protein-protein interactions of the PDZ domains of Zonula Occludens-1 |
| 15:50 - 16:05 |
Michal Toborek (University of Kentucky, USA) |
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GUT-Blood brain barrier axis in the enhancement of brain metastases by PCBs |
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16:00 - 16:30
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Break
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Session IIB:
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Transporters at the blood-brain barrier
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Chairs: David Miller (National Institute of Environmental Health Sciences, USA) & |
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Lester Drewes (University of Minnesota Medical School, USA) |
16:30 - 17:00
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David Miller (National Institute of Environmental Health Sciences, USA)
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Playing with signaling pathways that alter basal P-glycoprotein activity |
17:00 - 17:30
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Tetsuya Terasaki (Tohoku University, JP)
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Reconstitution of drug distribution in the monkey brain based on the
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blood-brain barrier MD1 protein quantification
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| 17:30 - 17:45 |
Md. Tozammel Hoque (University of Toronto, CAN) |
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Regulation of Breast Cancer Resistant Protein (BCRP) by Peroxisome Proliferator-Activated Receptor Alpha (PPARα) in Human Brain Microvessel Endothelial Cells |
| 17:45 - 18:00 |
Wangdong Zhang (Institute for Biological Sciences, CAN) |
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Generation and characterization of AD(Tg-SwDI)/Abcg2-knockout mice |
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| 19:00 |
Invited Speakers Dinner
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| 19:00 |
Young Scientists Party (Restaurant Luxor, Stationsweg 19, Leiden)
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Tickets can be bought at the registration desk for 35 Euro; this will include dinner and drinks. Please note that we can only accept cash payments. |
