Saturday June 25th
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VENUE: De Burcht, Burgsteeg 14, Leiden
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Session VII:
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Kinetics of blood-brain barrier drug transport and CNS effects in health and disease
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Chairs: Margareta Hammarlund-Udenaes (Uppsala University, SE) &
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Elizabeth de Lange (Leiden University, NL) |
09:30 - 10:00
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Quentin Smith (Texas Tech University Health Sciences Center, USA)
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Blood-brain barrier transport kinetics in experimental brain tumors
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10:00 - 10:30
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Elizabeth de Lange (Leiden University, NL)
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Role of blood-brain barrier transport in PKPD relationships of CNS drugs in health and disease |
10:30 - 10:50
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Ralph Clinckers (Free University of Brussels, BE)
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Blood-brain barrier drug transport changes in epilepsy
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| 10:50 - 11:10 |
Break |
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| 11:10 - 11:25 |
Stina Syvänen (Leiden University, NL) |
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Positron emission tomography and microdialysis studies for evaluation of the transporter hypothesis in epilepsy |
| 11:25 - 11:40 |
Muhammad Waqas Sadiq (Uppsala University, SE) |
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Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo |
| 11:40 - 11:55 |
Jens Bankstahl (University of Veterinary Medicine, DE) |
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Dose dependent transport of [11C]-labeled multidrug transporter inhibitors tariquidar and elacridar at the blood-brain barrier measured by small-animal PET and in-vitro-trasnport assays |
| 11:55 - 12:10 |
William Elmquist (University of Minnesota, USA) |
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Influence of BBB Efflux Transporters on Efficacy of Molecularly-Targeted Agents in a Novel Model of Glioma |
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| 12:10 - 13:00 |
Keynote lecture |
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Chair: Tetsuya Terasaki (Tohoku University, JP) |
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Margareta Hammarlund-Udenaes (Uppsala University, SE) |
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[sponsored by Douwe D. Breimer Research Foundation] |
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Methods to assess blood-brain barrier transport and brain distribution |
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Closure of meeting |
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Farewell lunch |
